8
September 2025. Role-players: 1. Nikita John, Shaima Abozeid.
Role-players:
2. Charlotte Plant, Ewa Ciolak.
|
35 |
Role-play 1. |
|
36 |
|
|
37 |
Viva. Apgar score |
|
38 |
EMQ. Hepatitis E |
|
39 |
EMQ. Peutz-Jeghers syndrome |
This is similar to the cancelled programme on
Monday, but I’ll change the role-plays as I don’t want you to have time to
prepare before the tutorial – it is best that we simulate the exam.
35.
Role-play
1. Candidate’s
instructions will be e-mailed shortly before the tutorial.
36.
Role-play
2. Candidate’s
instructions will be e-mailed shortly before the tutorial.
37.
Viva.
Topic will be revealed during
the tutorial.
Question 1.
What is the most
common cause of acute viral hepatitis in the UK?
|
A |
hepatitis A
virus |
|
B |
hepatitis B
virus |
|
C |
hepatitis C
virus |
|
D |
hepatitis D
virus |
|
E |
hepatitis E
virus |
|
F |
herpes simplex
virus |
|
G |
HIV |
Question 2.
Which, if any, of
the following are correct about HEV.
|
A |
it is a DNA
virus |
|
B |
it belongs to
the genus Hippieviridae |
|
C |
it belongs to
the genus Hepeviridae |
|
D |
it belongs to
the genus Hoppieviridae |
|
E |
there are six
main genotypes |
|
F |
genotype 3 is
the one of greatest importance in the UK |
|
G |
the main
reservoir of genotype 3 is intensively-reared chickens |
|
H |
the main
reservoir of genotype 3 is domestic cats |
|
I |
a vaccine
exists but is only licensed in Russia |
|
J |
none of the
above |
Question 3.
Which, if any, of
the following statements about HEV and pregnancy are true?
|
A |
pregnant women
are more susceptible to HEV infection |
|
B |
pregnant women
are more likely to develop serious disease that the non-pregnant |
|
C |
the main risk
is neonatal death due to vertical transmission |
|
D |
the main risk
is maternal death |
|
E |
the risk of
maternal death is highest with infection in the 1st. trimester |
|
F |
↑ rates
of preterm birth have been reported |
|
G |
↑ rates of stillbirth have been
reported |
39.
Peutz-Jeghers syndrome.
Abbreviations.
PJS: Peutz-Jeghers
syndrome.
Scenario 1.
Which, if any, of
the following are characteristics of PJS?
|
A |
buccal pigmentation |
|
B |
gastro-intestinal hamartomas |
|
C |
perianal pigmentation |
|
D |
increased risk of breast cancer |
|
E |
increased risk of cervical adenoma malignum |
|
F |
increased risk of colo-rectal cancer |
|
G |
increased risk of endometrial cancer |
|
H |
increased risk of ovarian cancer |
|
I |
increased risk of pancreatic cancer |
|
J |
increased risk of prostate cancer |
|
K |
increased risk of stomach cancer |
Scenario 2.
What is the
approximate prevalence of PJS?
|
A |
< 1 in 1,000 |
|
B |
1 in 1,000 to 1 in 10,000 |
|
C |
1 in 10,000 to 1 in 100,000 |
|
D |
1 in 25,000 to 1 in 100,000 |
|
E |
1 in 25,000 to 1 in 200,000 |
|
F |
1 in 25,000 to 1 in 300,000 |
|
G |
1 in 300,000 to 1 in 500,000 |
|
H |
< 1 in 500,000 |
Scenario 3.
What is the mode
of inheritance in PJS?
|
A |
autosomal dominant |
|
B |
autosomal recessive |
|
C |
X-linked dominant |
|
D |
X-linked recessive |
|
E |
Y-linked dominant |
|
F |
Y-linked recessive |
|
G |
triplet repeat |
Scenario 4.
Which, if any, of
the following statements are true of PJS?
|
A |
PJS only occurs in families with other affected members |
|
B |
PJS mainly occurs in families with other affected
members |
|
C |
PJS may arise de-novo in families with no other
affected members |
|
D |
PJS may arise de-novo in families with other affected
members |
|
E |
PJS does not arise de-novo in families with no other
affected members |
Scenario 5.
What is the
approximate lifetime risk of developing cancer in PJS?
|
A |
10% |
|
B |
20% |
|
C |
30% |
|
D |
40% |
|
E |
50% |
|
F |
60% |
|
G |
70% |
|
H |
80% |
|
I |
90% |
|
J |
>90% |
Scenario 6.
What is the
relevance of STK11 to PJS?
|
A |
It is part of the postcode of the Peutz-Jeghers Society |
|
B |
It is the name of the gene most commonly associated
with PJS |
|
C |
It is the Ornithological Society’s code for the Orkney
Skua |
|
D |
Somatic mutations have been found in cervical cancer |
|
E |
None of the above |
