Tutorial 31 January 2013

Tutorial.
Website.
Contact us.

Julie Morris will be giving a tutorial on medical statistics on Thursday 7th. February.
To get the most out of it you should revise your basic statistics and read the two tutorials on basic statistics on her website: http://www.south.manchester.ac.uk/medicalstatistics/information.asp

EMQ. Turner’s syndrome.           

With regard to prolactin.

1. What is it and what are its control mechanisms?                4 marks

2. Define and outline the main causes of hyperprolactinaemia.4 marks

3.  Critically evaluate prolactin in relation to fertility.             14 marks

A woman is to be admitted for a gynaecological procedure.

1. Outline why VTE is important and the strategies that hospital should employ to reduce their patients’ risks.                                                                                         

                                                                                                 4 marks.

2. Discuss how risk assessment should be done for this woman. 8 marks.

3. Outline the steps you will take to reduce her risk of VTE.       8 marks.              

A woman with BMI of 35 attends for pre-pregnancy counselling.

1. Outline the reasons that obesity is causing concern in relation to pregnancy. 6 marks

2. Justify the investigations you will arrange.                                                    2 marks

3.  Justify your management.                                                                          6 marks

4. Outline the key aspects of antenatal care.                                                6 marks.                   

With regard to female genital mutilation (FGM).

1. what are the key aspects of the law in the UK relating to FGM.   2 marks.

2. what are the responsibilities of the doctor who suspects that a child may be subjected to FGM? 

                                                                                                       2 marks.

3. how is FGM graded?                                                                  3 marks.

4.  outline the management of woman found at booking to have had FGM.     13 marks.

Turner’s  syndrome.

This is supposed to be an EMQ, but some of the questions are MCQ with “True” and “False” answers, so I have put these in the answer list. But it includes everything I think you might be asked about Turner’s.

Option list

1 in   500

1 in 1,000

1 in 1,500

1 in 2,000

1 in 2,500

1 in 3,000

1 in 10,000

1 in 50,000

0%

0.1%

1 %

2%

5%

10%

15%

20%

25%

30%

40%

50%

60%

70%

80%

90%

> 90%

Most common

2^nd. most common

True

False

Answer not on this option list.

Questions.

1.      TS is due to 45XO.                                                

2.      What is the incidence of TS?                                  

3.      The incidence of TS rises with maternal age?           .

4.      Most cases of TS are due to loss of a paternal chromosome. 

5.      How common in monosomy X in TS?                     

6.      How common is monosomy Y in TS?                     

7.      What % of miscarriages are due to TS?                  

8.      What % of TS pregnancies miscarry?                     

9.      ↑ NT is a feature of TS                                           

10.    ↑ NT is a feature of congenital heart disease           

11.    Low birth weight is a feature of TS.                         .

12.    If TS is suspected, but the neonate’s karyotype from blood testing is normal, the diagnosis is Noonan’s syndrome.                               .

13.    Neonates are at normal risk of developmental dysplasia of the hip. 

14.    Immune hydrops is more common in TS.                

15.    Cystic hygroma is more common in TS.                 

16.    What is the approximate risk of malignancy if there is XY mosaicism in TS?

17.    How common is webbing of the neck in TS?                       

18.    How common is a low occipital hairline in TS?                    

19.    How common is congenital heart disease in TS?     

20.    Dissecting aortic aneurysm is more common in TS.

21.    How common is lymphoedema in TS?                    

22.    How common is kidney disease in TS?                   

23.    Short stature in TS has been linked to the TS gene. 

24.    What % of adolescents with TS have scoliosis.       .

25.    Inverted nipples are more common in TS.               

26.    1ry. amenorrhoea occurs in all cases.                     

27.    Adrenarche occurs at a normal time.                       

28.    Cubitus valgus is more common in TS.                   

29.    Cleft palate if a feature of TS.                                

30.    Micrognathia is a feature of TS.                             

31.    Abnormalities of teeth and nails are more common in TS.    

32.    Otitis media is more common in TS.                                   

33.    Intelligence is usually lower in TS, especially verbal skills.   

34.    Women with TS have higher mortality rates than other women..

35.    Oestrogen should be started on diagnosis to promote bone growth.  .

36.    Oestrogen-only HRT is appropriate for bone protection.      

37.    Women with TS have an ↑ risk of hypertension.      

38.    Women with TS have an ↑ risk of coeliac disease.  

39.    Women with TS have an increased risk of Crohn’s disease and ulcerative colitis. 

40.    Women with TS have an ↑ risk of diabetes              

41.    Women with TS have an ↑ risk of hyperthyroidism.  

42.    Women with TS have an ↑ risk of deafness. .

43.    Women with TS have an ↑ risk of osteoporosis.

44.    Women with TS have similar rates of red-green colour blindness as men.  

45.    Women with TS have a normal incidence of ptosis. 

46.    Women with TS cannot have children.

47.    The “short stature homeobox” (SHOX) gene has been implicated in TS