Thursday 9 February 2017

Tutorial 9th. February 2017

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9 February 2017.

74
EMQ. Gestational trophoblastic disease
75
EMQ. Gp B streptococcus
76
SBA. Needle-stick and related injuries
77
SBA.  Sutures and needles

Question 74.     EMQ. Gestational Trophoblastic Disease (GTD)
Abbreviations.
APSN:    atypical placental site nodules
GI:         gastro-intestinal
GTD:     gestational trophoblastic disease
GTN:     Gestational trophoblastic neoplasia.
PSTT:     placental site trophoblastic tumour
Option list.
A.       
100%.
B.       
20%.
C.       
15%.
D.       
10%.
E.        
5%.
F.        
2.5%.
G.       
1.5%.
H.       
0.5%.
I.         
1 in 35.
J.         
1 in 55.
K.        
1 in 65.
L.        
1 in 700.
M.     
1 in 1,000.
N.       
Ö64.
O.      
pr2.
P.        
increased.
Q.      
reduced.
R.       
increased by a factor of 2.
S.        
increased by a factor of 5.
T.        
increased by a factor of 10.
U.       
increased by a factor of 20.
V.       
increased by a factor of 30.
W.     
increased by a factor of > 100.
X.        
hydatidiform mole, both partial and complete.
Y.        
hydatidiform mole, both partial and complete and placental site tumour.
Z.        
partial mole, complete mole, invasive and metastatic mole, choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour.
AA.   
choriocarcinoma invasive and metastatic mole and epithelioid trophoblastic tumour.
BB.   
true
CC.   
false
DD.  
None of the above.
Scenario 1.
List the conditions included in the term GTD. There is no option list, just make a list.
Scenario 2.
What is the difference between GTD and GTN? Pick one option from the list below.
Option list.
A
GTD comprises the non-malignant conditions, i.e. complete and partial moles.
GTN comprises the malignant conditions: invasive mole, choriocarcinoma and PSTT
B
GTD comprises all the trophoblastic conditions; GTN comprises the malignant conditions
C
GTD comprises all the trophoblastic conditions; GTN comprises persistent GTD
D
GTD comprises all the trophoblastic conditions; GTN comprises malignant and potentially malignant conditions, including atypical placental site nodules
E
none of the above
Scenario 3.
What is the incidence of GTD in the UK?
Scenario 4.
Which of the following statements, if any, are true of complete hydatidiform molar pregnancy?
A
they are usually diploid and of androgenic origin
B
are usually triploid, with 2 sets of paternal haploid genes + 1 set of maternal haploid genes
C
are usually triploid, with 1 set of paternal haploid genes + 2 sets of maternal haploid genes
D
are tetraploid or mosaics in up to 10% of cases
E
up to 80% are due to duplication of a single sperm in an egg devoid of maternal chromosomes
F
up to 80% are due to duplication of a single sperm in a normal egg
G
usually result from dispermic fertilisation of a normal egg
H
usually result from dispermic fertilisation of an egg devoid of maternal chromosomes
I
usually has 46XX makeup
J
usually has 46XY makeup
K
the presence of fetal red blood cells defines a mole as partial
L
mitochondrial DNA is maternal
M
mitochondrial DNA is paternal
Scenario 5.
Which of the following statements, if any, are true of partial hydatidiform molar pregnancy?
A
they are usually diploid and of androgenic origin
B
are usually triploid, with 2 sets of paternal haploid genes + 1 set of maternal haploid genes
C
are usually triploid, with 1 set of paternal haploid genes + 2 sets of maternal haploid genes
D
are tetraploid or mosaics in up to 10% of cases
E
up to 80% are due to duplication of a single sperm in an egg devoid of maternal chromosomes
F
up to 80% are due to duplication of a single sperm in a normal egg
G
usually result from dispermic fertilisation of a normal egg
H
usually result from dispermic fertilisation of an egg devoid of maternal chromosomes
I
usually has 46XX makeup
J
usually has 46XY makeup
K
the presence of fetal red blood cells defines a mole as partial
L
mitochondrial DNA is maternal
M
mitochondrial DNA is paternal
Scenario 6.
Which, if any, of the following statements are true in relation to GTN?
A
always arises from molar pregnancy
B
may occur after normal pregnancy and livebirth
C
may arise as primary ovarian neoplasia
D
the incidence after complete molar pregnancy is greater than after partial molar pregnancy
E
the incidence after livebirth is estimated at 1 in 50,000
Scenario 7
A woman had a complete mole in her first pregnancy. She is pregnant for the second time. What is the risk that it is another molar pregnancy?
Scenario 8
A woman has had two molar pregnancies. What is the risk of molar pregnancy if she becomes pregnant again?
Scenario 9
A woman has had three molar pregnancies. What is the risk of molar pregnancy if she becomes pregnant again?
Scenario 10
Which, if any, of the following statements are correct in relation to recurrence of molar pregnancy?
A
the histological type is likely to be the same
B
the histological type in recurrent mole after a complete mole is likely to be partial mole
C
the histological type in recurrent mole after a partial mole is likely to be complete mole
D
the histological type after PSTT is likely to be choriocarcinoma
E
none of the above
Scenario 11
Cystic placental spaces in the placenta and a ratio of transverse to anterioposterior
measurements of the gestation sac <1.5 are strongly suggestive of a partial mole. True / False.
Scenario 12.
What is the risk of persistent GTD after a complete mole?
Scenario 13
 What is the risk of requiring chemotherapy after a complete mole?
Scenario 14
What is the risk of persistent GTD after a partial mole?
Scenario 15
What is the risk of requiring chemotherapy after a partial mole?
Scenario 16
What is the risk of requiring chemotherapy with hCG level > 20,000 i.u. one month after evacuation?
Scenario 17
What is the overall risk of requiring chemotherapy after molar pregnancy in the UK?
Scenario 18
What is the risk of requiring chemotherapy in the USA compared with the UK?
Scenario 19
What is the risk of molar pregnancy at age < 15 compared to age 30?
Scenario 20
What is the risk of molar pregnancy at age > 45 compared to age 30?
Scenario 21
Which, if any,  of the following statements about hCG are true?
A
is a glycoprotein
B
shares its α sub-unit with FSH, LH & TSH
C
shares its α sub-unit with FSH & LH but not TSH
D
shares its β sub-unit with FSH, LH & TSH
E
shares its β sub-unit with FSH & LH but not TSH
F
β-core exists as a sub-type of β-hCG
G
nicked free-β exists as a sub-type of β-hCG
H
c-terminal peptide exists as a sub-type of β-hCG
I
hCG β core fragment may lead to false –ve results with urine pregnancy tests
J
heterophile antibodies may give false +ve hCG results
K
heterophile antibodies are not found in urine
Scenario 22
What are the risk factors included in the FIGO scoring system?
Question 75.     EMQ. Group B Streptococcus.
Abbreviations.
EOGBS:         early-onset GBS disease.
GBS:              Group B streptococcus.
IAP:               intrapartum antibiotic prophylaxis.
Option list.
1.       Streptococcus agaractiae
2.       Streptococcus intergalacticae
3.       Streptococcus agalactiae
4.       Streptococcus ubernastiae
5.       Lancelot
6.       Lanceforth
7.       Lanceford
8.       Landscape
9.       0.01%
10.   0.02%
11.   0.023%
12.   0.025%
13.   0.05%
14.   0.1%
15.   0.5%
16.   0.53%
17.   0.54%
18.   0.6%
19.   0.63%
20.   0.75%
21.   0.9%
22.   1%
23.   2%
24.   2.3%
25.   2.4%
26.   2.5%
27.   5%
28.   10%
29.   15%
30.   20%
31.   25%
32.   26.3%
33.   21%
34.   30%
35.   35%
36.   1
37.   2
38.   3
39.   5
40.   6
41.   9
42.   10
43.   True
44.   False
45.   you are driving me mad with all these percentages
Scenario 1.
What is the scientific name for GBS?
Scenario 2.
Which animal is the main reservoir of GBS in relation to neonatal GBS?
Scenario 2.
What system is used for grouping streptococci?
Scenario 3.
Where does GBS disease feature in the list of serious early-onset neonatal infection?
Scenario 4.
What is the upper limit in days for time of onset in the definition of “early-onset” disease?
Scenario 5.
GBS is a gram-negative, capsulated organism.
Scenario 6.
What is the incidence of EOGBS in the UK in the babies of women who have not been screened for GBS or had IAP?
Scenario 7
What is the incidence of EOGBS in the babies of American women who have had antenatal GBS screening and IAP if screen +ve?
Scenario 8
What is the mortality rate of EOGBS in the UK?

Question 76.     SBA. Needle-stick, sharps and related risks.
Abbreviations.
CMV:    cytomegalovirus
GBCV:   GB virus C
HAV:     hepatitis A virus
HBV:     hepatitis B virus
HCV:     hepatitis C virus
HDV:     hepatitis D virus
SOE:      significant occupational exposure to blood-borne infective agent.
VL:         viral load.
Question 1.
Lead-in
Approximately how many SOEs are reported annually in the UK?
Option List
A.       
~    100
B.       
~    250
C.       
~    500
D.       
~ 1,000
E.        
~ 5,000
Question 2.
Lead-in
Who was Ignac Phillip Semmelweis?
Option List
A.       
the person credited with demonstrating the infective nature of puerperal sepsis
B.       
the horticulturist who first grew the white flower subsequently popularised in the musical, “The sound of music”, naming it after his first wife, Eidel.
C.       
the person who first used antisepsis in aerosol form to reduce the risk of infection during  C. section.
D.       
the inventor of catgut sutures
E.        
the inventor of the Dalkon shield
Question 3.
Lead-in
Why does the name of Semmelweis’s colleague Kotecha live on in medical history?
Option List
A.       
he was the first doctor to perform hysterectomy
B.       
he was the first doctor know to undergo transgender surgery
C.       
he died of infection akin to puerperal sepsis after a SOE
D.       
he performed the first successful repair of a 3rd. degree perineal tear
E.        
none of the above
Question 4.
Lead-in
Which of the following have been described as causing infection after a SOE.
Infective agents
1.        
hepatitis A virus
2.        
hepatitis B virus
3.        
hepatitis C virus
4.        
human T cell leukaemia virus
5.        
malaria parasites
Option List
A.       
1 + 2 + 3 + 4 + 5
B.       
1 + 2 + 3 + 5
C.       
2 + 3 + 4 + 5
D.       
2 + 3 + 4
E.        
2 + 3 + 5
Question 5.
Lead-in
Which are the main causes of infection to cause concern in the UK in relation to SOEs?
Infective agents.
1.        
hepatitis A virus
2.        
hepatitis B virus
3.        
hepatitis C virus
4.        
HIV
5.        
treponema pallidum
Option List
A.       
1 + 2 + 3 + 4 + 5
B.       
1 + 2 + 3 + 4
C.       
1 + 2 + 3 + 5
D.       
2 + 3 + 4 + 5
E.        
2 + 3 + 4
Question 6.
Lead-in
Which group features most in the list of those reporting SOEs?
Option List
A.       
doctors
B.       
midwives
C.       
phlebotomists
D.       
nurses
E.        
other healthcare workers
Question 7.
Lead-in
Which clinical activity generates most SOEs?
Option List
A.       
acupuncture
B.       
assisting in the operating theatre
C.       
intramuscular drug / vaccine injection
D.       
subcutaneous drug / vaccine injection
E.        
venepuncture
Question 8.
Lead-in
Approximately how many cases of HIV seroconversion after SOE were recorded in the UK between 2004 and 2013?
Option List
A.       
0
B.       
1
C.       
20
D.       
100
E.        
500
Question 9.
Lead-in
Rate the following body fluids as: high or low risk in relation to infectivity.
Option List
A.       
amniotic fluid

B.       
blood

C.       
breast milk

D.       
cerebro-spinal fluid

E.        
faeces

F.        
peritoneal fluid

G.       
saliva

H.       
urine

I.         
urine – blood stained

J.         
vaginal fluid

K.        
vomit

Question 10.
Lead-in
Rate the following types of contact with body fluids as:
high-risk
low-risk
minimal or zero risk
Answer
A.       
exposure to faeces: not bloodstained

B.       
exposure to saliva: not bloodstained

C.       
exposure to urine: not bloodstained

D.       
exposure to vomit: not bloodstained

E.        
exposure via broken skin

F.        
exposure via intact skin

G.       
injury deep, percutaneous

H.       
exposure via mucosa

I.         
injury superficial

J.         
needle not used on source’s blood vessels

K.        
needle used on source’s blood vessels

L.        
sharps old

M.     
sharps recently used

N.       
sharps with blood not visible

O.      
sharps with blood visible sharps

Question 11.
Lead-in
Rate the following types of sources of potentially infective body fluids as:
high-risk
low-risk
minimal or zero risk
Answer
A.       
infected but VL and treatment details unknown

B.       
recent blood test negative for all relevant viruses

C.       
source has known risk factors but recent tests negative

D.       
viral status not known but source has known risk factors

E.        
viral status not known but source has no known risk factors

F.        
VL detectable

G.       
VL not detectable

H.       
VL unknown but on treatment with good adherence

Question 12.
Lead-in
Approximately how many cases of HBV seroconversion after SOE have been recorded in the UK since 1997?
Option List
A.       
0
B.       
1
C.       
20
D.       
100
E.        
500
Question 13.
Lead-in
Approximately how many cases of HCV seroconversion after SOE have been recorded in the UK since 1997?
Option List
A.       
0
B.       
1
C.       
20
D.       
100
E.        
500
Question 14.
Lead-in
What is the estimated risk of transmission of infection of HBV in a SOE involving sharps in a patient +ve for HBe antigen?
Option List

  1.  
1 in 2

  1.  
1 in 3

  1.  
1 in 30

  1.  
1 in 300

  1.  
 1 in 1,000 or less
Question 15.
Lead-in
What is the estimated risk of transmission of infection of HCV in a SOE involving sharps?
Option List

  1.  
1 in 2

  1.  
1 in 3

  1.  
1 in 30

  1.  
1 in 300

  1.  
 1 in 1,000 or less
Question 16.
Lead-in
What is the estimated risk of transmission of infection of HIV in a SOE involving sharps?
Option List

  1.  
1 in 2

  1.  
1 in 3

  1.  
1 in 30

  1.  
1 in 300

  1.  
 1 in 1,000 or less
Question 17.
Lead-in
What is the estimated risk of transmission of infection of HIV in a SOE involving mucosal splashing?
Option List

  1.  
1 in 2

  1.  
1 in 3

  1.  
1 in 30

  1.  
1 in 300

  1.  
 1 in 1,000 or less
Question 18.
Lead-in
Which of the following carries the highest risk of transmission of an infective agent after a SOE.
Option List
A.       
a bite on the bottom by an HIV-infected patient who finds your buttocks irresistible
B.       
deep injury from a scalpel wielded by a psychopathic surgeon
C.       
deep needle-stick after venepuncture
D.       
spitting by a patient with HIV
E.        
splash SOE from beating a disagreeable patient round the head with a frozen turkey because you are sick to death of their whingeing and perennial misery
Question 19.
Lead-in
List the steps you would take in relation to immediate first aid, including the things that might be suggested but you know are contraindicated.
Question 20.
Lead-in
Which tests should be performed on the source after obtaining consent?
List what you think should be done.
Option List
A.       
HBV surface antigen
B.       
HCV antibody
C.       
HCV RNA
D.       
HIV antigen and antibody (fourth generation HIV immunoassay)
E.        
TTV antibody
Question 21.
Lead-in
What consent is required from the source individual?
Option List
A.       
consent to having the tests
B.       
consent to having the results given to the occupational health department
C.       
consent to having the results given to the person who sustained the SOE
D.       
consent to having the results given to the hospital’s legal team
E.        
consent to notifying the hospital staff if the results are +ve.
Question 22.
Lead-in
What tests should be done on the person who has sustained the SOE and there is a significant risk of infection?
Option List
A.       
a baseline sample should be taken and stored for possible future use
B.       
HBV surface antibody
C.       
HCV antibody
D.       
HIV antigen and antibody
Question 23.
Lead-in
If there is a significant risk of HIV transmission, which of the following statements are correct in relation to when should PEP be given?
Option List
A.       
before the results of the tests done on the source are available
B.       
after the results of the tests done on the source are available
C.       
as soon as is practical
D.       
within 24 hours
E.        
within 72 hours
Question 24.
Lead-in
What are the recommended drugs for PEP in the UK?
Option List
A.       
Kaletra (200 mg lopinavir and 50 mg ritonavir)
B.       
Raltegravir 400 mg twice daily
C.       
Rifampicin 450-600mg daily as a single dose 
D.       
Tenofovir + lamivudine or emtricitabine
E.        
Truvada (245 mg tenofovir disoproxil fumarate and 200 mg emtricitabine)
Question 25.
Lead-in
Which of the following statements are correct in relation to PEP in early pregnancy
Option List
A.       
PEP is contraindicated until after 12 weeks
B.       
PEP should be started as for the non-pregnant
C.       
PEP should be started, but TOP should be offered
D.       
PEP should be started, but not until the puerperium
Question 26.
Lead-in
Which of the following statements is true in relation to reducing the risk of HCV infection.
Option List
A.       
HCV vaccine is safe in pregnancy and should be offered immediately
B.       
HCV vaccine is a live vaccine and contraindicated in pregnancy
C.       
acyclovir is an effective drug for prophylaxis
D.       
there is no known effective prophylactic drug
E.        
early treatment of HCV infection is effective, so SOE staff should be closely followed up for evidence of infection.

Question 77.     SBA. Sutures and needles.
Abbreviations
Eas:          external anal sphincter
Ias:           internal anal sphincter
OASI:       obstetric anal sphincter injury
SSI:           surgical site infection
Question 1.
Lead-in
What is the incidence of significant infection of abdominal surgical wounds?
Option List
F.        
≤ 1%
G.       
≤ 3%
H.       
≤ 5%
I.         
≤ 7%
J.         
≤ 10%
Question 2.
Lead-in
Which, if any, of the following statements are true in relation to SSIs?
Option List
A.       
pre-operative showering with antiseptic reduces the rate
B.       
pre-operative chemical depilation of the wound site halves the rate
C.       
povidone-iodine preparations are superior to those with chlorhexidine
D.       
alcohol based antiseptic preparations are superior to aqueous
E.        
antiseptic solutions should be applied using sponge not swab
Question 3.
Lead-in
Why do alcohol-based solutions carry more risk and how can these risks be minimised?
There is no option list – write your thoughts and compare them with my answer.
Question 4.
Lead-in
Which of the following terms are used to categorise suture materials?
Option List
F.        
natural
G.       
synthetic
H.       
monofilament
I.         
coated
J.         
none of the above
Question 5.
Which, if any, of the following are sources of catgut?
Option List
A.       
cats
B.       
cows
C.       
kangaroos
D.       
sheep
E.        
whales
Question 6.
Lead-in
Which of the following is closest to being the ideal suture material?
Option list
A.       
natural
B.       
synthetic
C.       
monofilament
D.       
coated
E.        
none of the above
Question 7.
Lead-in
What would be the key characteristics of the ideal suture?
There is no option list – write as many as you can dream up.
Question 7.
Lead-in
Which suture is recommended in GTG 29 for the repair of the anal mucosa in OASIs?
Option List
A.       
2-0 polyglactin
B.       
3-0 polyglactin
C.       
2-0 PDS
D.       
3-0 PDS
E.        
none of the above
Question 8.
Lead-in
Which, if any, of the following suturing techniques are recommended in GTG 29 for the repair of the anal mucosa in OASIs?
Option List
A.       
continuous suture
B.       
figure of 8 suture
C.       
interrupted sutures with the knot buried beneath the perineal muscles
D.       
interrupted sutures with the knots in the anal canal
E.        
submucosal suture like a subcuticular suture for skin
Question 9.
Lead-in
Which would be the most suitable suture for repair of the mesosalpinx during tubal re-anastomosis for reversal of sterilisation after tubal ligation?
Option List
F.        
Vicryl 0 on a cutting needle
G.       
Vicryl 2-0 on a cutting needle
H.       
Vicryl 2-0 on a round-bodied needle
I.         
Vicryl 3-0 on a cutting needle
J.         
Vicryl 3-0 on a round-bodied needle
Question 10.
Lead-in
Which would be the most suitable suture for the tubal surgery necessary during tubal re-anastomosis for reversal of sterilisation after tubal ligation?
Option List
A.       
Vicryl 3-0 on a cutting needle
B.       
Vicryl 3-0 on a round-bodied needle
C.       
Vicryl 5-0 on a cutting needle
D.       
Vicryl 5-0 on a round-bodied needle
E.        
Vicryl 7-0 on a cutting needle
F.        
Vicryl 7-0 on a round-bodied needle
Question 11.
Lead-in
You are performing Caesarean section on a woman who has had 2 previous sections. The bladder is very adherent. You separate it from the lower segment using sharp dissection and taking great care. You notice a 1 cm. defect in the dome of the bladder. The ureteric openings are far from the damage. Which suture would you use for the repair, assuming that you have the training and expertise to perform it?
Option List
F.        
Single-layer repair using interrupted sutures of 2-0 Vicryl
G.       
Two-layer repair using interrupted sutures of 2-0 Vicryl
H.       
Single-layer repair using interrupted sutures of 3-0 Vicryl
I.         
Two-layer repair using interrupted sutures of 3-0 Vicryl
J.         
None of the above
Question 12.
Lead-in
You are performing hysterectomy + bilateral salpingo-oophorectomy for menorrhagia and extensive endometriosis. After dissecting the right ovary free from adhesion  to the pelvic side-wall, you detect urine and note that the ureter has been cut. It is suitable for anastomosis.
Which of the following would you use for the repair, assuming that you have the training and expertise to perform it?
Option List
A.       
Single-layer repair using interrupted sutures of 2-0 Vicryl
B.       
Two-layer repair using interrupted sutures of 2-0 Vicryl + stent
C.       
Single-layer repair using interrupted sutures of 3-0 Vicryl
D.       
Two-layer repair using interrupted sutures of 3-0 Vicryl + stent
E.        
None of the above
Question 13.
Lead-in
An obese, woman of 80 years has a laparotomy for debulking of an ovarian malignancy via a mid-line incision. Which of the following would be most suitable for closing the abdomen.
Option List
A.       
0 Vicryl to muscle / fascia, 2-0 Vicryl to fat, interrupted 2-0 Vicryl to skin
B.       
0 Vicryl to muscle / fascia, 2-0 Vicryl to fat, interrupted 2-0 Vicryl to skin + fat drain
C.       
mass closure using 0 Vicryl, interrupted 2-0 Vicryl to skin
D.       
mass closure using 1 Vicryl, interrupted 2-0 Vicryl to skin
E.        
mass closure using 0 Prolene, interrupted 2-0 Vicryl to skin
Question 14.
Lead-in
You perform Caesarean section for a woman with a breech presentation. She had a mid-line lower abdominal scar resulting from a laparotomy some years before. She has requested that you use this scar and is aware of the slightly increased risk of dehiscence and hernia formation.
Which of the following best describes your decision re closing the abdomen.
Option List
A.       
close each layer separately using 0 Vicryl, don’t close peritoneum
B.       
mass closure using continuous 0 Prolene, peritoneum not closed
C.       
mass closure using interrupted 0 Prolene, peritoneum not closed
D.       
mass closure using continuous 0 Vicryl, peritoneum not closed
E.        
mass closure using 0 Vicryl, peritoneum closed
Question 15.
Lead-in
You perform Caesarean section for a primigravida with a breech presentation. When you close the uterus, which of the following statements will govern the technique you use.
Option List
A.       
the uterus should be exteriorised to maximise access
B.       
the uterus should be explored digitally to exclude retained products, e.g. a succenturiate lobe of the placenta
C.       
the uterus should be cleaned out with a swab to remove any debris
D.       
double-layer closure is recommended
E.        
closure of the pelvic peritoneum is recommended
Question 16.
Lead-in
A parous woman has a normal delivery, then a PPH. All conservative measures fail to arrest the bleeding and you decide to insert a uterine compression suture. Which of the following statements would apply to what you do.
Option List
A.       
place and inflate an intrauterine balloon before inserting the suture to maximise the effect.
B.       
exteriorise the uterus to reduce the risk of injury to bowel when placing sutures
C.       
use 1 Vicryl or 1PDS
D.       
use a curved needle of diameter at least 6 cm.
E.        
none of the above

 We will discuss the CPD questions from TOG. 16.1




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