Monday 24 November 2014

Tutorial 24 November 2014

24 November 2014.

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24 November 2014.

1
SBA.  Cancer incidence & mortality
2
EMQ. Cowden syndrome
3
Air Travel & Pregnancy. SIP 1. 2013. Extract key facts for Qs.
4
EMQ. Cystic fibrosis.

Cancer incidence and mortality.

Question 1.
Lead-in
What is the most common female cancer?
Option List
  1.  
Bowel
  1.  
Breast
  1.  
Cervix
  1.  
Endometrium
  1.  
Lung

Question 2.
Lead-in
What is the 2nd. most common female cancer?
Option List
  1.  
Bowel
  1.  
Breast
  1.  
Cervix
  1.  
Endometrium
  1.  
Lung

Question 3.
Lead-in
What is the 3rd. most common female cancer.
Option List
  1.  
Bowel
  1.  
Breast
  1.  
Cervix
  1.  
Endometrium
  1.  
Lung

Question 4.
Lead-in
What is the 4th. most common female cancer.
Option List
  1.  
Bowel
  1.  
Breast
  1.  
Cervix
  1.  
Endometrium
  1.  
Lung


Question 5.
Lead-in
What is the 5th. most common female cancer?
Option List
  1.  
Cervix
  1.  
Non-Hodgkin’s lymphoma
  1.  
Ovary
  1.  
Skin
  1.  
Vulva

Question 6.
Lead-in
What is the most common cancer causing female death in the UK?
Option List
  1.  
Breast
  1.  
Bowel
  1.  
Lung
  1.  
Ovary
  1.  
Pancreas

Question 7.
Lead-in
What is the 2nd. most common cancer causing female death in the UK?
Option List
  1.  
Breast
  1.  
Bowel
  1.  
Lung
  1.  
Ovary
  1.  
Pancreas

Question 8.
Lead-in
What is the 3rd. most common cancer causing female death in the UK?
Option List
  1.  
Breast
  1.  
Bowel
  1.  
Lung
  1.  
Ovary
  1.  
Pancreas

Question 9.
Lead-in
What is the 4th. most common cancer causing female death in the UK?
Option List
  1.  
Brain
  1.  
Oesophagus
  1.  
Ovary
  1.  
Pancreas
  1.  
Uterus

Question 10.
Lead-in
What is the 5th. most common cancer causing female death in the UK?
Option List
  1.  
Brain
  1.  
Oesophagus
  1.  
Ovary
  1.  
Pancreas
  1.  
Uterus


Cowden syndrome.

Abbreviations.
BRRs:    Bannayan-Riley-Ruvalcaba syndrome.
Cs:         Cowden syndrome.
PTEN:    Phosphatase and tensin homolog.

Lead-in
Which of the following statements are true?
Option List
A
Features of Cs are hamartoma formation and an increased risk of breast and endometrial cancer.
B
A minority of those with Cs have reduced intellect.
C
Most cases are due to mutations in the PTEN gene and inheritance in an AD pattern.
D
Most cases are due to mutations in the PTEN gene and inheritance in an AR pattern.
E
Cs and BRRs are thought to be part of the same disease spectrum


1.        
A
2.        
A + B
3.        
A + B + C
4.        
A + B + D
5.        
A + B + C + E
6.        
A + B + D + E
7.        
B + C
8.        
B + D
9.        
B + C + E
10.    
B + D + E


This question is about cystic fibrosis.
For each scenario choose the option that gives the best answer.
Each option can be used once, more than once or not at all.
And, to make you behave in a model fashion, there is no option list, so you have to decide the correct answer.
Scenario 1.
A woman is 8 weeks pregnant and known to be a carrier of cystic fibrosis.
Her husband is Caucasian.
What is the risk of the child having cystic fibrosis?
Scenario 2.
A healthy woman attends for pre-pregnancy counselling.
Her brother has cystic fibrosis. Her husband is Caucasian.
He has been screened for cystic fibrosis. The test was negative.
What is the risk of them having a child with cystic fibrosis?
Scenario 3.
A healthy woman is a known carrier of cystic fibrosis.
She attends for pre-pregnancy counselling. Her husband has cystic fibrosis.
What is the risk of them having a child with CF?
Scenario 4.
A healthy woman attends for pre-pregnancy counselling. Her sister has had a child with cystic fibrosis.
What is her risk of being a carrier?
Scenario 5.
A woman attends for pre-pregnancy counselling. Her mother has cystic fibrosis.
What is the risk that she is a carrier?
Scenario 6 .
A woman attends for pre-pregnancy counselling. Her mother has cystic fibrosis.
The partner’s risk of being a carrier is 1 in X.
What is the risk that she will have a child with CF?
Scenario 7.
A healthy Caucasian woman is 10 weeks pregnant.
Her husband is a known carrier of cystic fibrosis.
Which test would you arrange?
Scenario 8.
A woman attends for pre-pregnancy counselling. She has read about diagnosing CF using cffDNA from maternal blood. Is it possible to test for CF in this way?
Scenario 9.
A woman and her husband are known carriers of cystic fibrosis.
What is the risk of them having an affected child.
Scenario 10.
A woman and her husband are known carriers of cystic fibrosis.
What can they do to reduce the risk of having an affected child?
Scenario 11.
A woman and her husband are known carriers of cystic fibrosis.
Can CVS exclude an affected pregnancy?
Scenario 12.
A woman with cystic fibrosis has a normal delivery of a healthy, 3.2 kg. baby at term. She has been advised not to breastfeed because her breast milk will be protein-deficient due to malabsorption.
Is this advice correct?
Scenario 13.
A woman with cystic fibrosis has a normal delivery of a healthy, 3.2 kg. baby at term. She has been advised not to breastfeed because her breast milk will contain abnormally low levels of sodium.
Is this advice correct?




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