Sunday 20 August 2023

Tutorial 21st. August 2023

Contact me

Website


29

Role-play. Freebirth.

30

Structured discussion. The uses of MgSO4 in O&G

31

Blurb. Autosomal recessive condition

32

EMQ. The MAGPIE trial 

33

EMQ. Brexanolone

 

29.      Role-play. Freebirth.

Candidate’s instructions.

You are an SpR5 in charge of the antenatal clinic as the consultant is on sick leave. Ms Jones has attended the booking clinic but the midwives don’t know what to do with her as she does not wish to be booked. They have asked you to see her. Your tasks are to deal with her as you would in real life.

GP letter.

The Health Centre,

Utopia-on-Sea.

Re Helen Jones,

287 Main Street,

Utopia-on-Sea.

 

Dear Doctor,

Ms Jones has an appointment in the booking clinic when she will be about 10 weeks advanced in her first pregnancy. She intends to have no medical or midwifery care during the pregnancy or labour and delivery, planning what she calls ‘free birth’ after reading newspaper reports about the dangers of maternity hospitals. I have not come across ‘free birth’ before and plan to speak to my medical defence body about the implications for the medical and midwifery staff at the Health Centre.

Ms. Jones wishes to attend the booking clinic, but not to book! Her wishes are to arrange screening for Down’s syndrome and she would like to have a 20-week scan to check the baby looks normal, but does not want any other involvement with the maternity department or its staff.

She is an intelligent and articulate young woman with no significant health record. Her only dealings with the Health Centre have been to have cervical smears, which have been normal, prescriptions for the Pill and treatment a couple of years ago for a badly-sprained ankle.

I shall be most appreciative of your advice in this matter. I have asked her to return to see me and the midwife after the hospital visit so that we can clarify what we can do to help her and our responsibilities in this matter, which, I am sure are going to cause the professionals with whom she has dealings a lot of head-scratching.

John Williams. FRCGP.

 

30.      Structured discussion. The uses of MgSO4 in O&G.

Candidate’s instructions.

This is a structured discussion about the uses of MgSO4 in O&G, but it is an extreme example. The examiner will not ask questions, prompt or otherwise assist. It is up to you to give as full an account of the uses as you can muster.

 

31.      Blurb. Autosomal recessive condition.

Discussion of the key facts to include in this blurb and its possible wording.

 

32.      The MAGPIE trial.

It is useful to have the basic facts to show how smart you are in a viva.

Question 1.   Which of the following is true of the Magpie trial?

Option list.

A

it compared MgSO4 with placebo in the management of eclampsia / severe PET

B

it compared MgSO4 with lytic cocktail in the management of eclampsia / severe PET

C

it compared MgSO4 with phenytoin in the management of eclampsia / severe PET

D

it compared MgSO4 with alcohol in the management of threatened premature labour

E

it compared MgSO4 with atosiban in the management of threatened premature labour

F

it compared MgSO4 with ritodrine in the management of threatened premature labour

G

it compared MgSO4 with dexamethasone in the prevention of cerebral palsy due to extreme prematurity

H

it compared MgSO4 with placebo in the prevention of cerebral palsy due to extreme prematurity

I

none of the above

Question 2.   Which if any of the following are true of the Magpie trial?

Option list.

A

it involved ~ 1,000 women

B

it involved ~ 10,000 women

C

it involved ~ 20,000 women

C

it involved > 20,000 women

D

it involved ~ 30 hospitals

E

it involved ~ 50 hospitals

F

it involved ~ 80 hospitals

G

it involved > 150 hospitals

H

it involved 5 countries

I

it involved 10 countries

J

it involved 20 countries

K

it involved 30 countries

L

it involved 50 countries

M

it involved >50 countries

Question 3.   Which if any of the following are true?

Option list.

A

almost 50% of the women were in Africa

B

almost 50% of the women were in America

C

almost 50% of the women were in Asia

D

almost 50% of the women were in Australia / New Zealand

E

almost 50% of the women were in Europe

Question 4.   Which, if any, of the following is true of the Magpie trial?

Option list.

A

cerebral palsy rates at 2 years were ↓ by the use of MgSO4 in babies born < 34 weeks

B

cerebral palsy rates at 2 years were unchanged  by the use of MgSO4 in babies born < 34 week

C

eclampsia rates were reduced by about half by the use of MgSO4

D

eclampsia rates were reduced by about half by the use of MgSO4 but only in underdeveloped countries

E

maternal mortality was significantly ↓ by the use of MgSO4

F

maternal mortality was significantly ↓ by the use of MgSO4, but only in underdeveloped countries

G

premature delivery was significantly ↓ by the use of MgSO4

H

perinatal mortality from prematurity was significantly ↓ by the use of MgSO4

 

33.      Brexanolone.

Abbreviations.

GABAA: γ-aminobutyric acid type A.

Scenario 1.    Which, if any, of the following statements are true?

Option list.

A

Brexanolone it is a water soluble form of allopregnanolone

B

allopregnanolone is an oestrogen metabolite and levels mirror those of oestrogen

C

allopregnanolone is a potent modulator of GABAA receptors in the brain

D

brexanolone is effective in the treatment of postpartum depression

E

brexanolone is administered orally

F

brexanolone is licensed for use in the UK

 

 


Wednesday 16 August 2023

Tutorial 17th. August 2023

 

Contact me

Website

24

Role-play. Anencephaly

25

Blurb. The GP referral letter

26

Blurb. Agenda setting in Part 3 station

27

EMQ Surrogacy

28

SBA. McCune Albright syndrome

 24.      Role-play. Anencephaly.

Candidate’s instructions.

You are an SpR5 and running the ante-natal clinic – your consultant has been called to help a consultant colleague with an emergency on the labour unit and is not available for advice.

You are about to see Jean Hathersage. She is 25 years old and had a 10-week scan last week that showed anencephaly. She stated that she did not want TOP. She was counselled, given information leaflets and asked to return to the antenatal clinical today for further discussion.

Your task is to conduct that discussion.

 

25.      Blurb. The GP referral letter.

We will discuss the possible content of a ‘blurb’.

26.      Blurb. Agenda setting in Part 3 station.

As for 25.

27.      Surrogacy.

Surrogacy.

Pick the best choice from the option list for each scenario.

Abbreviations.

ART:         assisted reproductive technology

Bhatia:    Bhatia K, Martindale E, Rustamov O & Nysenbaum A:  “Surrogate pregnancy: an essential guide for clinicians”. TOG. 2009;11:49-54.

B&O:       Burrell & O’Connor. TOG 2013. “Surrogate pregnancy: ethical and medico-legal issues in modern obstetrics.” TOG. 2013;15:113-19.

CF:           commissioning father

CM:          commissioning mother

CPs:         commissioning parents

PO:           parental order

SM:          surrogate mother

Option List.

a)       CM

b)      CF

c)       CPs

d)      SM

e)      Chairman of the HFEA

f)        Senior judge at the Children and Family Court

g)       traditional surrogacy

h)      gestational surrogacy

i)        HFEA

j)        SSAEW

k)       RCOG Surrogacy Sub-Committee

l)        false

m)    true

n)      none of the above

 

Scenario 1.  List the different types of surrogacy.

Scenario 2. “Gestational” surrogacy has better “take-home-baby” rates than “traditional” surrogacy.

Scenario 3. There are approximately 1,000 surrogate pregnancies per annum in the UK. True/False

Scenario 4. Which national body regulates surrogacy in England?

Scenario 5. Privately-arranged surrogate pregnancies are illegal and those involved are liable to up to 2 years in prison.                                                                                                                          True/False

Scenario 6. List the risks of surrogacy.

Scenario 7. Obstetricians are legally obliged to take the CPs’ wishes into consideration in managing pregnancy complications or problems.

Scenario 8. The psychological outcomes of surrogacy are fully understood.                        True/False.

Scenario 9. The psychological outcomes of surrogacy are more severe after traditional surrogacy.

 True/False

Scenario 10. Who has the right to arrange TOP if the fetus is found to have a major congenital abnormality?

Scenario 11. A SM decides at 10 weeks that she does not wish to be pregnant and arranges to have a TOP. The CPs. hear about this and object strongly. To whom should they apply to have the TOP blocked?

Scenario 12. A woman has hysterectomy and BSO to deal with extensive endometriosis at the age of 30. She marries two years later and her sister offers to act as surrogate. She undergoes IVF and 4 embryos are created. One is transferred and a successful pregnancy ensues. The baby is adopted by the woman and her husband. The 3 remaining embryos were frozen. Four years later the woman falls out with her sister, but finds another surrogate and wishes to proceed with another pregnancy. The sister says she does not want her eggs to be used and that the frozen embryos should not be transferred. Does the sister have the legal right to block the use of the embryos?    Yes / No.

Scenario 13. A girl born from donor sperm reaches the age of 16 and wishes to know the identity of her genetic father. Does she have the right to this information?                                                   Yes / No.

Scenario 14. A girl born from donor sperm reaches the age of 18 and wins a place at Oxford University to read medicine. Does she have the legal right to get the donor to contribute to her fees?

Yes / No.

Scenario 15. A PO is active from the moment it is completed and signed by the relevant parties. 

True/False

Scenario 16. A SM can change her mind at any time and keep the child, even if the egg was not hers. 

True/False

Scenario 17. The CPs can change their mind, leaving the SM as the legal mother.         True/False

Scenario 18. A SM’s husband is the legal father until adoption is completed or a PO comes into force.

True/False

Scenario 19. A lesbian couple in a stable, co-habiting relationship can be CPs and become the legal parents of the child of a SM.                                                                                                        True/False

Scenario 20. CPs are likely to get faster legal status as the legal parents through application for a PO rather than applying for adoption.                                                                                         True/False

 

TOG questions. See B&O in Abbreviations.

With regard to different types of surrogacy,

1.     the practice of ‘straight surrogacy’ produces a child who has no genetic link to the surrogate mother.                                                                                                                                     True/False

When medical interventions in pregnancy (such as amniocentesis) are recommended,

2.     a doctor should obtain consent from both the commissioning parents and the surrogate if the baby is the genetic child of the commissioning mother.                                                 True/False

3.     In 2013, professional medical bodies are totally opposed to surrogacy arrangements in the UK.                                                                                                                                            True/False

After delivery,

4.     the community healthcare visitor should only visit a baby if it resides with the surrogate mother.                                                                                                                                       True/False

If the surrogate mother has a miscarriage,

5.     the doctor may be asked to provide evidence to support this.                               True/False

Commissioning parents,

6.     previously knew the surrogate mother in about 10% of cases.                               True/False

7.     are free to consent to medical treatment for the baby while waiting for parental responsibility to be granted, provided that the child resides with them.                                            True/False

With regard to the surrogacy contract,

8.     it is legally enforceable and therefore the involvement of the Trust’s legal team is unnecessary.                                                                                                                                         True/False

With regard to current legislation surrounding the practice of surrogacy in the UK,

9.     the introduction of The Human Fertilisation and Embryology Act 1990 makes it likely that there will be more cases of surrogacy in the future.                                                                True/False

10.   if the surrogate or a foreign commissioning parent domiciles in the UK, then UK laws apply regardless of where conception occurred.                                                                          True/False

11.   organisations and agencies involved are legally allowed to operate in the UK, and can charge membership fees provided that they operate on a non-profit basis.                                        True/False

12.   if a surrogate mother feels emotional and unsure about handing over the baby to the intended parents after birth, since she has already accepted payment from the intended parents she is bound by the terms of her contract and must continue with the arrangement.       True/False

13.   advertising the availability of surrogate service is illegal in the UK.                        True/False

Regarding parental responsibility,

14.   the court will grant a parental order if the commissioning couple are either married or cohabitees and both are >16 years old.                                                                     True/False

15.   a parental order can only be granted to a same-sex couple if they have been together for at least 10 years.                                                                                                                         True/False

16.   the commissioning couple should apply for parental responsibility within 6 months after the birth of the child.                                                                                                                         True/False

With regard to the surrogate mother,

17.   if she changes her mind about handing over the baby after birth, it is possible that she may be able to retain legal custody of the child if she has a genetic link to the child.                        True/False

18.   if her husband was unaware that his wife underwent artificial insemination and became pregnant as a surrogate, he is still the legal father of the child.                              True/False

If a woman has donated an egg,

19.   she is legally considered to be the mother of the child.                                            True/False

The commissioning mother,

20.   will be entitled to normal maternity rights with her employer if she has a genetic link to the child.                                                                                                                            True/False

 

28.      SBA. McCune Albright syndrome.

Abbreviations.

CPP:      central precocious puberty.

MCA:    McCune Albright syndrome.

PFD:      polyostotic fibrous dysplasia.

PP:         precocious puberty.

These are not true SBAs as there may be > 1 correct answer – laziness on my part as it saves typing!

Scenario 1.    Which, if any, of the following are components of the classical triad of MCA?

Option List

A

albinism

B

“cafè Cubano” spots

C

“Coast of California” pigmented areas

D

lentigo

E

macroorchidism

F

osteomalacia

G

polyostotic fibrous dysplasia

H

precocious puberty

I

premature menopause

J

primary amenorrhoea

Scenario 2.    Which, if any, of the following are true in relation to MCA?

Option List

A

it is an example of central primary amenorrhoea

B

it is an example of central secondary amenorrhoea

C

it is an example of central precocious puberty

D

it is an example of peripheral primary amenorrhoea

E

it is an example of peripheral secondary amenorrhoea

F

it is an example of peripheral precocious puberty

G

none of the above

Scenario 3.    Which, if any, of the following are believed to be true in relation to the abnormality of

onset of puberty associated with MCA?

Option List

A

it is due to abnormal FSH production

B

it is due to abnormal LH production

C

it may be due to abnormal androgen production

D

it may be due to abnormal oestrogen production

E

it is linked to ovarian cysts with malignant potential

F

none of the above

Scenario 4.    Which, if any, of the following are true in relation to polyostotic fibrous dysplasia?

Option List

A

polyostotic means resembling parrot bone

B

polyostotic means resembling pigeon bone

C

polyostotic means affecting long bones

D

fibrous dysplasia refers to replacement of marrow by fibrous tissue

E

PFD is a variant of osteomalacia

F

PFD may be unilateral

G

PFD is associated with a 1% risk of malignancy

Scenario 5.    Which, if any, of the following are true in relation to MCA?

Option List

A

hyperthyroidism is common

B

hypothyroidism is common

C

thyroid function is similar to those without MCA

Scenario 6.    Which, if any, of the following are true in relation to MCA?

Option List

A

excess growth hormone production  is common

B

inadequate growth hormone production is common

C

growth hormone production is similar to those without MCA

Scenario 7.    Which, if any, of the following is true in relation to MCA?

Option List

A

inheritance is autosomal dominant

B

inheritance is autosomal recessive

C

inheritance is X-linked dominant

D

inheritance is X-linked recessive

E

inheritance is multifactorial

F

it is not a hereditary disorder

G

it is not genetic

H

none of the above

Scenario 8.    Which, if any, of the following are true in relation to MCA?

Option List

A

renal artery stenosis is more common

B

renal cortex wasting is more common

C

renal phosphate wasting is more common

D

renal waisting is more common

E

none of the above.

Scenario 9.    Approximately what % of children born to women with MCAS will have MCAS?

Option List

A

0

B

1 in 105 - 106

C

1 in 104

D

1 in 100

E

1 in 50

F

1 in 10

G

1 in 2

H

All

 

 

TOG includes MCAS in CPD Questions for volume 14, number 2, 2012, which are open access, so reproduced here. There are only two questions on MCAS. Note that the second includes CPP.

McCune–Albright syndrome

1. is caused by activating mutations of the GNAS1 gene.                                            True / False

2. is characterised by polyostotic fibrous dysplasia, café-au-lait spots and CPP.      True / False